Klasemen Serie A Italia Musim 2020-2021 menunjukkan rekor setiap tim di turnamen sepanjang musim yang akan selalu diupdate setiap saat setelah pertandingan berakhir.
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | SSC Napoli | 27 | 23 | 2 | 2 | 64 | 16 | +48 | 71 |
| 2 | Lazio | 27 | 15 | 7 | 5 | 42 | 19 | +23 | 52 |
| 3 | Inter Milan | 28 | 16 | 2 | 10 | 47 | 32 | +15 | 50 |
| 4 | AC Milan | 27 | 14 | 6 | 7 | 44 | 36 | +8 | 48 |
| 5 | Atalanta | 28 | 14 | 6 | 8 | 47 | 32 | +15 | 48 |
| 6 | Roma | 27 | 14 | 5 | 8 | 35 | 26 | +9 | 47 |
| 7 | Juventus | 28 | 18 | 5 | 5 | 46 | 22 | +24 | 44 |
| 8 | Fiorentina | 28 | 11 | 7 | 10 | 33 | 31 | +2 | 40 |
| 9 | Udinese | 27 | 9 | 11 | 7 | 37 | 31 | +6 | 38 |
| 10 | Bologna | 27 | 10 | 7 | 10 | 33 | 36 | -3 | 37 |
| 11 | Torino | 27 | 10 | 7 | 10 | 29 | 33 | -4 | 37 |
| 12 | Sassuolo | 27 | 10 | 6 | 11 | 35 | 40 | -5 | 36 |
| 13 | Monza | 27 | 9 | 7 | 11 | 32 | 37 | -5 | 34 |
| 14 | Empoli | 27 | 6 | 10 | 11 | 24 | 36 | -12 | 28 |
| 15 | Lecce | 27 | 6 | 9 | 12 | 24 | 32 | -8 | 27 |
| 16 | Salernitana | 27 | 6 | 9 | 12 | 31 | 47 | -16 | 27 |
| 17 | Spezia | 27 | 5 | 9 | 13 | 23 | 43 | -20 | 24 |
| 18 | Verona | 28 | 4 | 7 | 17 | 22 | 42 | -20 | 19 |
| 19 | Sampdoria | 27 | 3 | 6 | 18 | 16 | 44 | -28 | 15 |
| 20 | Cremonese | 28 | 1 | 10 | 17 | 23 | 52 | -29 | 13 |
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