Klasemen Serie A Italia Musim 2020-2021 menunjukkan rekor setiap tim di turnamen sepanjang musim yang akan selalu diupdate setiap saat setelah pertandingan berakhir.
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | SSC Napoli | 20 | 17 | 2 | 1 | 48 | 15 | +33 | 53 |
| 2 | Inter Milan | 20 | 13 | 1 | 6 | 40 | 26 | +14 | 40 |
| 3 | Lazio | 20 | 11 | 5 | 4 | 36 | 16 | +20 | 38 |
| 4 | Atalanta | 20 | 11 | 5 | 4 | 39 | 23 | +16 | 38 |
| 5 | AC Milan | 20 | 11 | 5 | 4 | 37 | 29 | +8 | 38 |
| 6 | Roma | 20 | 11 | 4 | 5 | 26 | 18 | +8 | 37 |
| 7 | Udinese | 20 | 7 | 8 | 5 | 28 | 22 | +6 | 29 |
| 8 | Torino | 20 | 7 | 6 | 7 | 21 | 22 | -1 | 27 |
| 9 | Bologna | 20 | 7 | 5 | 8 | 26 | 30 | -4 | 26 |
| 10 | Empoli | 20 | 6 | 8 | 6 | 19 | 24 | -5 | 26 |
| 11 | Monza | 20 | 7 | 4 | 9 | 25 | 28 | -3 | 25 |
| 12 | Fiorentina | 20 | 6 | 6 | 8 | 22 | 26 | -4 | 24 |
| 13 | Juventus | 20 | 11 | 5 | 4 | 30 | 17 | +13 | 23 |
| 14 | Salernitana | 20 | 5 | 6 | 9 | 25 | 38 | -13 | 21 |
| 15 | Lecce | 20 | 4 | 8 | 8 | 19 | 24 | -5 | 20 |
| 16 | Sassuolo | 20 | 5 | 5 | 10 | 23 | 31 | -8 | 20 |
| 17 | Spezia | 20 | 4 | 6 | 10 | 17 | 32 | -15 | 18 |
| 18 | Verona | 20 | 3 | 4 | 13 | 18 | 32 | -14 | 13 |
| 19 | Sampdoria | 20 | 2 | 3 | 15 | 8 | 34 | -26 | 9 |
| 20 | Cremonese | 20 | 0 | 8 | 12 | 15 | 35 | -20 | 8 |
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